Multifunctional Small Molecules as Potential Anti-Alzheimer's Disease Agents.

ABSTRACT: Alzheimer's disease (AD) is a severe multifactorial neurodegenerative disorder characterized by a progressive loss of neurons in the brain. Despite research efforts, the pathogenesis and mechanism of AD progression are not yet completely understood. There are only a few symptomatic drugs approved for the treatment of AD. The multifactorial character of AD suggests that it is important to develop molecules able to target the numerous pathological mechanisms associated with the disease. Thus, in the context of the worldwide recognized interest of multifunctional ligand therapy, we report herein the synthesis, characterization, physicochemical and biological evaluation of a set of five (1a-e) new ferulic acid-based hybrid compounds, namely feroyl-benzyloxyamidic derivatives enclosing differen

SUBMITTER: Bargagna B 

PROVIDER: S-EPMC8512147 | biostudies-literature | 2021 Oct

REPOSITORIES: biostudies-literature