Stem Cells from Human Exfoliated Deciduous teeth Promote Hair Regeneration in Mouse.

ABSTRACT: Stem cells in different types may interact with each other to maintain homeostasis or growth and the interactions are complicated and extensive. There is increasing evidence that mesenchymal-epithelial interactions in early morphogenesis stages of both tooth and hair follicles show many similarities. In order to explore whether stem cells from one tissue could interact with cells from another tissue, a series of experiments were carried out. Here we successfully extracted and identified stem cells from human exfoliated deciduous teeth (SHED) of 8-12 years old kids, and then found that SHED could promote hair regeneration in a mouse model. In vitro, SHED shortened the hair regeneration cycle and promoted the proliferation and aggregation of dermal cells. In vivo, when SHED and skin cells of

SUBMITTER: Zhang X 

PROVIDER: S-EPMC8512255 | biostudies-literature | 2021 Jan-Dec

REPOSITORIES: biostudies-literature