Co-Density Distribution Maps for Advanced Molecule Colocalization and Co-Distribution Analysis.

ABSTRACT: Cellular and subcellular spatial colocalization of structures and molecules in biological specimens is an important indicator of their co-compartmentalization and interaction. Presently, colocalization in biomedical images is addressed with visual inspection and quantified by co-occurrence and correlation coefficients. However, such measures alone cannot capture the complexity of the interactions, which does not limit itself to signal intensity. On top of the previously developed density distribution maps (DDMs), here, we present a method for advancing current colocalization analysis by introducing co-density distribution maps (cDDMs), which, uniquely, provide information about molecules absolute and relative position and local abundance. We exemplify the benefits of our method by developi

SUBMITTER: De Santis I 

PROVIDER: S-EPMC8513075 | biostudies-literature | 2021 Sep

REPOSITORIES: biostudies-literature