Cannabinoid Receptor 2 Alters Social Memory and Microglial Activity in an Age-Dependent Manner.

ABSTRACT: Physiological brain aging is characterized by gradual, substantial changes in cognitive ability, accompanied by chronic activation of the neural immune system. This form of inflammation, termed inflammaging, in the central nervous system is primarily enacted through microglia, the resident immune cells. The endocannabinoid system, and particularly the cannabinoid receptor 2 (CB₂R), is a major regulator of the activity of microglia and is upregulated under inflammatory conditions. Here, we elucidated the role of the CB₂R in physiological brain aging. We used CB₂R^-/- mice of progressive ages in a behavioral test battery to assess social and spatial learning and memory. This was followed by detailed immunohistochemical analysis of microglial activit

SUBMITTER: Komorowska-Muller JA 

PROVIDER: S-EPMC8513097 | biostudies-literature | 2021 Oct

REPOSITORIES: biostudies-literature