Direct Airway Instillation of Neutrophils Overcomes Chemotactic Deficits Induced by Injury.

ABSTRACT:

Background

Trauma induces neutrophil migration toward injury sites, both initiating wound healing and protecting against local bacterial infection. We have previously shown that mitochondrial formyl peptides (mtFPs) released by injured tissues act as chemoattractants by ligating neutrophil (PMN) formyl peptide receptor 1 (FPR1). But this process can also internalize multiple neutrophil chemoattractant receptors and thus might limit neutrophil migration to the lung in response to bacteria. Our objective was to better understand susceptibility to pneumonia after injury and thus find ways to reverse it.

Methods and results

We modeled the alveolar chemotactic environment in pulmonary infections by incubating Staphylococcus aureus or Escherichia coli with peripheral blood mononuc

SUBMITTER: Zhang Q 

PROVIDER: S-EPMC8513109 | biostudies-literature | 2021 Jul

REPOSITORIES: biostudies-literature