Intra-patient stability of tumor mutational burden from tissue biopsies at different time points in advanced cancers.

ABSTRACT:

Background

Tumor mutational burden (TMB) may be a predictive biomarker of immune checkpoint inhibitor (ICI) responsiveness. Genomic landscape heterogeneity is a well-established cancer feature. Molecular characteristics may differ even within the same tumor specimen and undoubtedly evolve with time. However, the degree to which TMB differs between tumor biopsies within the same patient has not been established.

Methods

We curated data on 202 patients enrolled in the PREDICT study (NCT02478931), seen at the University of California San Diego (UCSD), who had 404 tissue biopsies for TMB (two per patient, mean of 722 days between biopsies) to assess difference in TMB before and after treatment in a pan-cancer cohort. We also performed an orthogonal analysis of 2872 paired pan-so

SUBMITTER: Pham TV 

PROVIDER: S-EPMC8513181 | biostudies-literature | 2021 Oct

REPOSITORIES: biostudies-literature