Tissue-resident M2 macrophages directly contact primary sensory neurons in the sensory ganglia after nerve injury.

ABSTRACT:

Background

Macrophages in the peripheral nervous system are key players in the repair of nerve tissue and the development of neuropathic pain due to peripheral nerve injury. However, there is a lack of information on the origin and morphological features of macrophages in sensory ganglia after peripheral nerve injury, unlike those in the brain and spinal cord. We analyzed the origin and morphological features of sensory ganglionic macrophages after nerve ligation or transection using wild-type mice and mice with bone-marrow cell transplants.

Methods

After protecting the head of C57BL/6J mice with lead caps, they were irradiated and transplanted with bone-marrow-derived cells from GFP transgenic mice. The infraorbital nerve of a branch of the trigeminal nerve of wild-type mic

SUBMITTER: Iwai H 

PROVIDER: S-EPMC8513227 | biostudies-literature | 2021 Oct

REPOSITORIES: biostudies-literature