Intestinal microbiota has important effect on severity of hand foot and mouth disease in children.

ABSTRACT:

Background

The incidence of hand foot and mouth disease (HFMD) has increased in recent years, making it a very common childhood illness worldwide. The relationship between different enterovirus genotypes and disease severity is not clearly understood. Given that enteroviruses are transmitted through the gastrointestinal tract, we hypothesized that variation in intestinal microorganisms of the host might play a role in the prognosis of HFMD.

Methods

We carried out a meta-transcriptomic-wide association study of fecal samples obtained from a cohort of children (254 patients, 227 tested positive for enterovirus, including 16 patients co-infectied with 2 kinds of enterovirus) with mild and severe HFMD and healthy controls.

Results

We found there was no significant differe

SUBMITTER: Shen C 

PROVIDER: S-EPMC8513321 | biostudies-literature | 2021 Oct

REPOSITORIES: biostudies-literature