Quantitative proteomics reveals the effect of Yigu decoction (YGD) on protein expression in bone tissue.

ABSTRACT:

Background

Osteoporosis (OP) is a systemic bone disease characterized by decreased bone mass, destruction of the bone tissue microstructure, increased bone brittleness and an increased risk of fracture. OP has a high incidence rate and long disease course and is associated with serious complications. Yigu decoction (YGD) is a compound prescription in traditional Chinese medicine that is used to treat OP. However, its mechanism in OP is not clear. This study used a tandem mass tag (TMT)quantitative proteomics method to explore the potential bone-protective mechanism of YGD in an osteoporotic rat model.

Materials and methods

A rat model of OP was established by ovariectomy. Eighteen 12-week-old specific-pathogen-free female Wistar rats weighing 220 ± 10 g were selected. The ei

SUBMITTER: Zhang R 

PROVIDER: S-EPMC8513338 | biostudies-literature | 2021 Oct

REPOSITORIES: biostudies-literature