Antibiotic heteroresistance in Mycobacterium tuberculosis isolates: a systematic review and meta-analysis.

ABSTRACT:

Background

Mycobacterium tuberculosis (MTB) is responsible for tuberculosis; that continues to be a public health threat across the globe. Furthermore, increasing heteroresistance (HR)-the presence of resistant and susceptible isolates among MTB strains- has been reported from around the world. This phenomenon can lead to full resistance development and treatment failure.

Methods

We systematically searched the relevant studies in PubMed, Scopus, and Embase (Until October 21, 2020). The study outcomes revealed the weighted pooled prevalence of antibiotic HR in MTB isolates with subgroup analysis by year, quality of study, and heteroresistance detection method.

Results

A total of 38 studies which had investigated MTB isolates were included in the meta-analysis. Geograph

SUBMITTER: Ye M 

PROVIDER: S-EPMC8513340 | biostudies-literature | 2021 Oct

REPOSITORIES: biostudies-literature