Catalytically active gold clusters with atomic precision for noninvasive early intervention of neurotrauma.

ABSTRACT:

Background

Neurotrauma is a worldwide public health problem which can be divided into primary and secondary damge. The primary damge is caused by external forces and triggers the overproduction of peroxides and superoxides, leading to long-lasting secondary damage including oxidative stress, wound infection and immunological reactions. The emerging catalysts have shown great potential in the treatment of brain injury and neurogenic inflammation, but are limited to biosafety issues and delivery efficiency.

Results

Herein, we proposed the noninvasive delivery route to brain trauma by employing highly active gold clusters with enzyme-like activity to achieve the early intervention. The decomposition rate to H₂O₂ of the ultrasmall gold clusters is 10 times

SUBMITTER: Zhang Y 

PROVIDER: S-EPMC8513369 | biostudies-literature | 2021 Oct

REPOSITORIES: biostudies-literature