Targeted molecular characterization of external auditory canal squamous cell carcinomas.

ABSTRACT:

Hypothesis

Squamous cell carcinomas (SCC) of the external auditory canal (EAC) may harbor unique genomic alterations that may explain aggressive behavior and differentiate these tumors from cutaneous SCCs of other subsites.

Background

EAC SCCs arise in a non-ultraviolet-exposed region of the head and neck, are often locally aggressive and may metastasize to lymph nodes or distant sites. The genomic alterations underlying cutaneous SCC of other sites are well-documented; however, mutational profiles of EAC SCC are less well characterized and may contribute to the unique anatomic site, high rates of recurrence and tumor spread. We performed targeted sequencing of a cohort of primary EAC SCCs to identify recurring and potentially targetable genomic alterations.

Methods

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SUBMITTER: Basura GJ 

PROVIDER: S-EPMC8513438 | biostudies-literature | 2021 Oct

REPOSITORIES: biostudies-literature