Milestones toward cochlear gene therapy for patients with hereditary hearing loss.

ABSTRACT: A number of genes are reportedly responsible for hereditary hearing loss, which accounts for over 50% of all congenital hearing loss cases. Recent advances in genetic testing have enabled the identification of pathogenic variants in many cases, and systems have been developed to provide personalized treatment based on etiology. Gene therapy is expected to become an unprecedented curative treatment. Several reports have demonstrated the successful use of cochlear gene therapy to restore auditory function in mouse models of genetic deafness; however, many hurdles remain to its clinical application in humans. Herein, we focus on the frequency of deafness genes in patients with congenital and late-onset progressive hearing loss and discuss the following points regarding which genes need to be

SUBMITTER: Yoshimura H 

PROVIDER: S-EPMC8513455 | biostudies-literature | 2021 Oct

REPOSITORIES: biostudies-literature