Zika Virus Infection of Pregnant Ifnar1^-/- Mice Triggers Strain-Specific Differences in Fetal Outcomes.

ABSTRACT: Zika virus (ZIKV) is a flavivirus that causes a constellation of adverse fetal outcomes collectively termed congenital Zika syndrome (CZS). However, not all pregnancies exposed to ZIKV result in an infant with apparent defects. During the 2015 to 2016 American outbreak of ZIKV, CZS rates varied by geographic location. The underlying mechanisms responsible for this heterogeneity in outcomes have not been well defined. Therefore, we sought to characterize and compare the pathogenic potential of multiple Asian-/American-lineage ZIKV strains in an established Ifnar1^-/- pregnant mouse model. Here, we show significant differences in the rate of fetal demise following maternal inoculation with ZIKV strains from Puerto Rico, Panama, Mexico, Brazil, and Cambodia. Rates of fetal de

SUBMITTER: Bohm EK 

PROVIDER: S-EPMC8513483 | biostudies-literature | 2021 Oct

REPOSITORIES: biostudies-literature