Variation in oral microbiome is associated with future risk of lung cancer among never-smokers.

ABSTRACT:

Objective

To prospectively investigate whether diversity in oral microbiota is associated with risk of lung cancer among never-smokers.

Design and setting

A nested case-control study within two prospective cohort studies, the Shanghai Women's Health Study (n=74 941) and the Shanghai Men's Health Study (n=61 480).

Participants

Lifetime never-smokers who had no cancer at baseline. Cases were subjects who were diagnosed with incident lung cancer (n=114) and were matched 1:1 with controls on sex, age (≤2 years), date (≤30 days) and time (morning/afternoon) of sample collection, antibiotic use during the week before sample collection (yes/no) and menopausal status (for women).

Main outcomes and measures

Metagenomic shotgun sequencing was used to measure the communit

SUBMITTER: Hosgood HD 

PROVIDER: S-EPMC8513501 | biostudies-literature | 2021 Mar

REPOSITORIES: biostudies-literature