Cleaved Delta like 1 intracellular domain regulates neural development via Notch signal-dependent and -independent pathways.

ABSTRACT: Notch-Delta signaling regulates many developmental processes, including tissue homeostasis and maintenance of stem cells. Upon interaction of juxtaposed cells via Notch and Delta proteins, intracellular domains of both transmembrane proteins are cleaved and translocate to the nucleus. Notch intracellular domain activates target gene expression; however, the role of the Delta intracellular domain remains elusive. Here, we show the biological function of Delta like 1 intracellular domain (D1ICD) by modulating its production. We find that the sustained production of D1ICD abrogates cell proliferation but enhances neurogenesis in the developing dorsal root ganglia (DRG), whereas inhibition of D1ICD production promotes cell proliferation and gliogenesis. D1ICD acts as an integral component of l

SUBMITTER: Okubo Y 

PROVIDER: S-EPMC8513606 | biostudies-literature | 2021 Oct

REPOSITORIES: biostudies-literature