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Using (+)-Carvone to access novel derivatives of (+)-ent-Cannabidiol: the first asymmetric syntheses of (+)-ent-CBDP and (+)-ent-CBDV.
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ABSTRACT:
SUBMITTER: Golliher AE
PROVIDER: S-EPMC8513745 | biostudies-literature | 2021 Mar
REPOSITORIES: biostudies-literature
Publications
Using (+)-Carvone to access novel derivatives of (+)-<i>ent</i>-Cannabidiol: the first asymmetric syntheses of (+)-<i>ent</i>-CBDP and (+)-<i>ent</i>-CBDV.
Tetrahedron letters 20210205
(-)-Cannabidiol [(-)-CBD] has recently gained prominence as a treatment for neuro-inflammation and other neurodegenerative disorders; interest is also developing in its synthetic enantiomer, (+)-CBD, which has a higher affinity to CB1 / CB2 receptors than the natural stereoisomer. We have developed an inexpensive, stereoselective route to access <i>ent</i>-CBD derivatives using (+)-carvone as a starting material. In addition to (+)-CBD, we report the first syntheses of (+)-cannabidivarin, (+)-ca ...[more]