Regional biomechanical and failure properties of healthy human ascending aorta and root.

ABSTRACT:

Purpose

Aortic dissection (AD) is a life-threatening event that occurs when the intimal entry tear propagates and separates inner from outer layers of the aorta. Diameter, the current criterion for aneurysm repair, is far from ideal and additional evidence to optimize clinical decision would be extremely beneficial. Biomechanical investigation of the regional failure properties of aortic tissue is essential to understand and proactively prevent AD. We previously studied biaxial mechanical properties of healthy human aorta. In this study, we investigated the regional failure properties of healthy human ascending aorta (AscAo) including sinuses of Valsalva (SOV), and sinotubular junction (STJ).

Results

A total of 430 intact tissue samples were harvested from 19 healthy donors

SUBMITTER: Xuan Y 

PROVIDER: S-EPMC8513753 | biostudies-literature | 2021 Nov

REPOSITORIES: biostudies-literature