Hepcidin induces intestinal calcium uptake while suppressing iron uptake in Caco-2 cells.

ABSTRACT: Abnormal calcium absorption and iron overload from iron hyperabsorption can contribute to osteoporosis as found in several diseases, including hemochromatosis and thalassemia. Previous studies in thalassemic mice showed the positive effects of the iron uptake suppressor, hepcidin, on calcium transport. However, whether this effect could be replicated in other conditions is not known. Therefore, this study aimed to investigate the effects of hepcidin on iron and calcium uptake ability under physiological, iron uptake stimulation and calcium uptake suppression. To investigate the potential mechanism, effects of hepcidin on the expression of iron and calcium transporter and transport-associated protein in Caco-2 cells were also determined. Our results showed that intestinal cell iron uptake w

SUBMITTER: Phoaubon S 

PROVIDER: S-EPMC8513844 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature