Redox and catalase-like activities of four widely used carbon monoxide releasing molecules (CO-RMs).

ABSTRACT: The pathophysiological roles of the endogenous signaling molecule, carbon monoxide (CO), have been extensively studied and validated in cell culture and animal models. Further, evidence supporting the therapeutic effects of CO in various human diseases has been mounting over the last two decades. Along this line, there has been intensive interest in developing various delivery forms including CO gas, CO in solution, metal-carbonyl complexes widely known as CO-releasing molecules (CO-RMs), and organic CO prodrugs. Among them, two ruthenium-based carbonyl complexes, CORM-2 and -3, occupy a very special place because they have been used in over 500 published studies. One of the mechanisms for CO's actions is known to be through attenuation of oxidative stress and regulation of production of r

SUBMITTER: Yuan Z 

PROVIDER: S-EPMC8513939 | biostudies-literature | 2021 Oct

REPOSITORIES: biostudies-literature