Clinical Correlates and Implications of the Reliability of the Frailty Index in the Canadian Longitudinal Study on Aging.

ABSTRACT:

Background

Deficit accumulation frailty indices (FIs) are widely used to characterize frailty. FIs vary in number and composition of items; the impact of this variation on reliability and clinical applicability is unknown.

Method

We simulated 12 000 studies using a set of 70 candidate deficits in 12 080 community-dwelling participants 65 years and older. For each study, we varied the number (5, 10, 15, 25, 35, 45) and composition (random selection) of items defining the FI and calculated descriptive and predictive estimates: frailty score, prevalence, frailty cutoff, mortality odds ratio, predicted probability of mortality for FI = 0.28 (prevalence threshold), and FI cutoff predicting 10% mortality over the follow-up. We summarized the estimates' medians and spreads (0.025-0

SUBMITTER: Nguyen QD 

PROVIDER: S-EPMC8514068 | biostudies-literature | 2021 Oct

REPOSITORIES: biostudies-literature