The porcine accessory carpal bone as a model for biologic joint replacement for trapeziometacarpal osteoarthritis.

ABSTRACT: Given its complex shape and relatively small size, the trapezium surface at the trapeziometacarpal (TMC) joint is a particularly attractive target for anatomic biologic joint resurfacing, especially given its propensity to develop osteoarthritis, and the limited and sub-optimal treatment options available. For this to advance to clinical translation, however, an appropriate large animal model is required. In this study, we explored the porcine accessory carpal bone (ACB) as a model for the human trapezium. We characterized ACB anatomy, geometry, joint and tissue-scale mechanics, and composition across multiple donors. We showed that the ACB is similar both in size, and in the saddle shape of the main articulating surface to the human trapezium, and that loads experienced across each joint

SUBMITTER: Stoeckl BD 

PROVIDER: S-EPMC8514079 | biostudies-literature | 2021 Jul

REPOSITORIES: biostudies-literature