Dataset Information
Side effects of omeprazole: a system biology study.
Ontology highlight
ABSTRACT: Aim
To assess the effects of omeprazole on the human cardiovascular system is the main aim of this study.Background
Omeprazole as a proton pump inhibitor is widely consumed to inhibit gastric acid secretion.Methods
Gene expression profiles of "human coronary artery endothelial cells" in the absence and presence of omeprazole were downloaded from the Gene Expression Omnibus (GEO) database. The differentially expressed genes (DEGs) interacted as an interactome, and the hub nodes are determined. The DEGs were enriched via gene ontology (GO) analysis. The critical hubs were identified based on the GO findings.Results
Among 103 queried DEGs, 61 individuals were included in the main connected component. CTNNB1, HNRNPA1, SRSF4, TRA2A, SFPQ, and RBM5 genes were identified as critical hub genes. Six clusters of biological terms were introduced as deregulated elements in the presence of omeprazole.Conclusion
In conclusion, long-term consumption of omeprazole may be accompanied with undesirable effects, however more evidence is required.
SUBMITTER: Hamzeloo-Moghadam M
PROVIDER: S-EPMC8514216 | biostudies-literature | 2021
REPOSITORIES: biostudies-literature
Publications
Side effects of omeprazole: a system biology study.
Gastroenterology and hepatology from bed to bench 20210101 4
<h4>Aim</h4>To assess the effects of omeprazole on the human cardiovascular system is the main aim of this study.<h4>Background</h4>Omeprazole as a proton pump inhibitor is widely consumed to inhibit gastric acid secretion.<h4>Methods</h4>Gene expression profiles of "human coronary artery endothelial cells" in the absence and presence of omeprazole were downloaded from the Gene Expression Omnibus (GEO) database. The differentially expressed genes (DEGs) interacted as an interactome, and the hub ...[more]
