Side effects of omeprazole: a system biology study.

ABSTRACT:

Aim

To assess the effects of omeprazole on the human cardiovascular system is the main aim of this study.

Background

Omeprazole as a proton pump inhibitor is widely consumed to inhibit gastric acid secretion.

Methods

Gene expression profiles of "human coronary artery endothelial cells" in the absence and presence of omeprazole were downloaded from the Gene Expression Omnibus (GEO) database. The differentially expressed genes (DEGs) interacted as an interactome, and the hub nodes are determined. The DEGs were enriched via gene ontology (GO) analysis. The critical hubs were identified based on the GO findings.

Results

Among 103 queried DEGs, 61 individuals were included in the main connected component. CTNNB1, HNRNPA1, SRSF4, TRA2A, SFPQ, and RBM5 genes were iden

SUBMITTER: Hamzeloo-Moghadam M 

PROVIDER: S-EPMC8514216 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature