Increased risk of cancer in patients with primary sclerosing cholangitis.

ABSTRACT:

Background and aims

Primary sclerosing cholangitis (PSC) is associated with an increased risk of hepatobiliary and colorectal cancer, but the risks of other cancer forms have not been explored. The aim of this study was to evaluate the risk of intestinal and extraintestinal cancers in a large, well-defined cohort of PSC patients.

Material and method

A matched cohort study of Swedish PSC patients was performed with up to ten comparators for each patient, matched for sex, age, and residency. The data were retrieved from national registers. Patients were followed from PSC diagnosis until cancer diagnosis, liver transplantation, first emigration date, death, or December 31, 2016. The risk of cancer was estimated using the Kaplan-Meier method and Cox regression models.

Results

SUBMITTER: Lundberg Bave A 

PROVIDER: S-EPMC8514354 | biostudies-literature | 2021 Oct

REPOSITORIES: biostudies-literature