Immunotherapy in prostate cancer: new horizon of hurdles and hopes.

ABSTRACT:

Purpose

Prostate cancer (PCa) is the most common malignancy in men and the cause for the second most common cancer-related death in the western world. Despite ongoing development of novel approaches such as second generation androgen receptor targeted therapies, metastatic disease is still fatal. In PCa, immunotherapy (IT) has not reached a therapeutic breakthrough as compared to several other solid tumors yet. We aimed at highlighting the underlying cellular mechanisms crucial for IT in PCa and giving an update of the most essential past and ongoing clinical trials in the field.

Methods

We searched for relevant publications on molecular and cellular mechanisms involved in the PCa tumor microenvironment and response to IT as well as completed and ongoing IT studies and scree

SUBMITTER: Tsaur I 

PROVIDER: S-EPMC8514362 | biostudies-literature | 2021 May

REPOSITORIES: biostudies-literature