Influence of dietary intervention on microvascular endothelial function in coronary patients and atherothrombotic risk of recurrence.

ABSTRACT: Endothelial dysfunction is a key player in both the onset and development of atherosclerosis. No study has examined whether healthy dietary patterns can improve microvascular endothelial function in patients with coronary heart disease (CHD) in the long-term and whether this relationship can affect patient's risk of CHD recurrence. In the CORDIOPREV study, a randomized, double-blind, controlled trial, dietary intervention with either the Mediterranean diet or a low-fat diet was implemented in 1,002 CHD patients. A laser-doppler flowmetry was performed at baseline and after 6 years of follow up in 664 patients, evaluating the effects of this dietary intervention on microvascular basal flow and reactive hyperaemia area, as well as on the risk of CHD recurrence, based on the TRS2P risk score.

SUBMITTER: Millan-Orge M 

PROVIDER: S-EPMC8514425 | biostudies-literature | 2021 Oct

REPOSITORIES: biostudies-literature