Targeted clearance of senescent cells using an antibody-drug conjugate against a specific membrane marker.

ABSTRACT: A wide range of diseases have been shown to be influenced by the accumulation of senescent cells, from fibrosis to diabetes, cancer, Alzheimer's and other age-related pathologies. Consistent with this, clearance of senescent cells can prolong healthspan and lifespan in in vivo models. This provided a rationale for developing a new class of drugs, called senolytics, designed to selectively eliminate senescent cells in human tissues. The senolytics tested so far lack specificity and have significant off-target effects, suggesting that a targeted approach could be more clinically relevant. Here, we propose to use an extracellular epitope of B2M, a recently identified membrane marker of senescence, as a target for the specific delivery of toxic drugs into senescent cells. We show that an antib

SUBMITTER: Poblocka M 

PROVIDER: S-EPMC8514501 | biostudies-literature | 2021 Oct

REPOSITORIES: biostudies-literature