SUMOylation of Arginyl tRNA Synthetase Modulates the Drosophila Innate Immune Response.

ABSTRACT: SUMO conjugation of a substrate protein can modify its activity, localization, interaction or function. A large number of SUMO targets in cells have been identified by Proteomics, but biological roles for SUMO conjugation for most targets remains elusive. The multi-aminoacyl tRNA synthetase complex (MARS) is a sensor and regulator of immune signaling. The proteins of this 1.2 MDa complex are targets of SUMO conjugation, in response to infection. Arginyl tRNA Synthetase (RRS), a member of the sub-complex II of MARS, is one such SUMO conjugation target. The sites for SUMO conjugation are Lys 147 and 383. Replacement of these residues by Arg (RRS ^K147R,K383R ), creates a SUMO conjugation resistant variant (RRS ^SCR ). Transgenic Drosophila lines for R

SUBMITTER: Nayak P 

PROVIDER: S-EPMC8514731 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature