The Multi-Omic Prognostic Model of Oxidative Stress-Related Genes in Acute Myeloid Leukemia.

ABSTRACT: Background: Acute myeloid leukemia (AML) is one of the most common cancers in the world, and oxidative stress is closely related to leukemia. A lot of effort has been made to improve the prognosis of AML. However, the situation remains serious. Hence, we focused on the study of prognostic genes in AML. Materials and Methods: Prognostic oxidative stress genes were screened out. The gene expression profile of AML patients was downloaded from the The Cancer Genome Atlas (TCGA) database. The oxidative stress-related model was constructed, by which the prognosis of AML patients was predicted using the two GEO GSE23143 datasets and the stability of the GSE71014 authentication model. Results: The prognostic oxidative stress genes were screened out in AML, and the prognostic g

SUBMITTER: Dong C 

PROVIDER: S-EPMC8514868 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature