Quantitative Imaging of Blood-Brain Barrier Permeability Following Repetitive Mild Head Impacts.

ABSTRACT: This was an exploratory study designed to evaluate the feasibility of a recently established imaging modality, quantitative ultrashort time-to-echo contrast enhanced (QUTE-CE), to follow the early pathology and vulnerability of the blood brain barrier in response to single and repetitive mild head impacts. A closed-head, momentum exchange model was used to produce three consecutive mild head impacts aimed at the forebrain separated by 24 h each. Animals were measured at baseline and within 1 h of impact. Anatomical images were collected to assess the extent of structural damage. QUTE-CE biomarkers for BBB permeability were calculated on 420,000 voxels in the brain and were registered to a bilateral 3D brain atlas providing site-specific information on 118 anatomical regions. Blood brain ba

SUBMITTER: Leaston J 

PROVIDER: S-EPMC8515019 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature