Kidney Function and Aortic Stiffness, Pulsatility, and Endothelial Function in African Americans: The Jackson Heart Study.

ABSTRACT:

Rationale & objective

The relation of vascular stiffness, endothelial function, and kidney function is incompletely elucidated in African Americans. Our hypothesis was that increased vascular stiffness and endothelial dysfunction are associated with low estimated glomerular filtration rate (eGFR) and albuminuria in African Americans.

Study design

Cross-sectional cohort analysis of data from the Jackson Heart Study.

Settings & patients

2,244 Jackson Heart Study participants (2012-2017 after Exam 3) who had undergone noninvasive hemodynamic assessment using arterial tonometry.

Predictors

Baseline carotid-femoral pulse wave velocity, pulsatile hemodynamics forward wave amplitude, and hyperemic brachial artery flow were measured. Reduced eGFR was defined as eGFR be

SUBMITTER: Nagarajarao HS 

PROVIDER: S-EPMC8515070 | biostudies-literature | 2021 Sep-Oct

REPOSITORIES: biostudies-literature