A systematic review and meta-analysis of the effectiveness and adverse events of gabapentin and pregabalin for sciatica pain.

ABSTRACT:

Aim

This SR aims to assess the effectiveness of pregabalin and gabapentin on pain and disability caused by acute sciatica and the adverse events associated with their clinical use.

Design

Systematic review.

Databases

Electronic databases of Cochrane Central Register of Controlled Trials, MEDLINE, EMBASE, and Clinical Trials.gov were searched from their inception until March 1st of 2021.

Selection criteria

Randomized trials (RCT) with adults>18 years old with acute sciatica for a minimum of 1 week and a maximum of 1 year (at least moderate pain).

Data treatment

The outcomes were pain, disability and adverse events. Data was summarized using odds ratio and mean difference. GRADE was used to calculate the level of evidence.

Results

Eight RCT involvin

SUBMITTER: Gimenez-Campos MS 

PROVIDER: S-EPMC8515246 | biostudies-literature | 2022 Jan

REPOSITORIES: biostudies-literature