Association Between Hereditary Lobular Breast Cancer Due to CDH1 Variants and Gastric Cancer Risk.

ABSTRACT:

Importance

Hereditary cancer risk is informed by the presence of a germline gene variant more so than by family history of cancer.

Objective

To assess gastric cancer risk among patients who received a diagnosis of hereditary lobular breast cancer (HLBC) owing to a germline loss-of-function variant in CDH1 by establishing prevalence of signet ring cell carcinomas among asymptomatic patients.

Design, setting, and participants

A prospective cohort study of patients with germline CDH1 pathogenic or likely pathogenic (P/LP) variants at a quaternary medical center were enrolled between October 2017 and January 2021. Data analysis was performed in May 2021. Analyses for associations were performed for these 3 patient groups: (1) family history of breast cancer and no gastric

SUBMITTER: Gamble LA 

PROVIDER: S-EPMC8515254 | biostudies-literature | 2022 Jan

REPOSITORIES: biostudies-literature