The global Alzheimer's Association round robin study on plasma amyloid β methods.

ABSTRACT:

Introduction

Blood-based assays to measure brain amyloid beta (Aβ) deposition are an attractive alternative to the cerebrospinal fluid (CSF)-based assays currently used in clinical settings. In this study, we examined different blood-based assays to measure Aβ and how they compare among centers and assays.

Methods

Aliquots from 81 plasma samples were distributed to 10 participating centers. Seven immunological assays and four mass-spectrometric methods were used to measure plasma Aβ concentrations.

Results

Correlations were weak for Aβ42 while Aβ40 correlations were stronger. The ratio Aβ42/Aβ40 did not improve the correlations and showed weak correlations.

Discussion

The poor correlations for Aβ42 in plasma might have several potential explanations, such as th

SUBMITTER: Pannee J 

PROVIDER: S-EPMC8515356 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature