Relationship between objectively measured physical activity on neuropathology and cognitive outcomes in older adults: Resistance versus resilience?

ABSTRACT:

Introduction

Physical activity (PA) is associated with better cognitive and brain health. However, it remains unclear whether PA relates to accumulation of disease pathology ("resistance") or indirectly moderates adverse effects of pathology on cognition ("cognitive resilience").

Methods

Five hundred thirteen Rush Memory and Aging Project (MAP) decedents completed longitudinal actigraphy monitoring, cognitive testing, and neuropathological examination. Cross-sectional models tested the relationship between average PA and pathology, and the moderating effect of baseline PA on the association between pathology and cognition. Longitudinal models examined whether changes in PA moderated associations between pathology and cognition.

Results

PA was negatively associated wit

SUBMITTER: Memel M 

PROVIDER: S-EPMC8515358 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature