Microfluidic On-Chip Production of Alginate Hydrogels Using Double Coflow Geometry.

ABSTRACT: Microfluidic on-chip production of microgels employing external gelation has numerous biological and pharmaceutical applications, particularly for the encapsulation of delicate cargos; however, the on-chip production of microgels in microfluidic devices can be challenging due to problems such as clogging caused by accelerated progress in precursor solution viscosity. Here, we introduce a novel microfluidic design incorporating two consecutive coflow geometries for microfluidic droplet generation. A shielding oil phase is employed to avoid emulsification and gelation stages from occurring simultaneously, thereby preventing clogging. The results revealed that the microfluidic device could generate highly monodispersed spherical droplets (coefficient of variation < 3%) with an average diamete

SUBMITTER: Sattari A 

PROVIDER: S-EPMC8515369 | biostudies-literature | 2021 Oct

REPOSITORIES: biostudies-literature