Dataset Information

Hepatic Fibrosis Associates With Multiple Cardiometabolic Disease Risk Factors: The Framingham Heart Study.

ABSTRACT:

Background and aims

NAFLD is increasing in prevalence and will soon be the most common chronic liver disease. Liver stiffness, as assessed by vibration-controlled transient elastography (VCTE), correlates with hepatic fibrosis, an important predictor of liver-related and all-cause mortality. Although liver fat is associated with cardiovascular risk factors, the association between hepatic fibrosis and cardiovascular risk factors is less clear.

Approach and results

We performed VCTE, assessing controlled attenuation parameter (CAP; measure of steatosis) and liver stiffness measurement (LSM) in 3,276 Framingham Heart Study adult participants (53.9% women, mean age 54.3 ± 9.1 years) presenting for a routine study visit. We performed multivariable-adjusted logistic regression models to determine the association between LSM and obesity-related, vascular-related, glucose-related, and cholesterol-related cardiovascular risk factors. The prevalence of hepatic steatosis (CAP ≥ 290 dB/m) was 28.8%, and 8.8% had hepatic fibrosis (LSM ≥ 8.2 kPa). Hepatic fibrosis was associated with multiple cardiovascular risk factors, including increased odds of obesity (OR, 1.82; 95% CI, 1.35-2.47), metabolic syndrome (OR, 1.49; 95% CI 1.10-2.01), diabetes (OR, 2.67; 95% CI, 1.21-3.75), hypertension (OR, 1.52; 95% CI, 1.15-1.99), and low high-density lipoprotein cholesterol (OR, 1.47; 95% CI, 1.09-1.98), after adjustment for age, sex, smoking status, alcohol drinks/week, physical activity index, aminotransferases, and CAP.

Conclusions

In our community-based cohort, VCTE-defined hepatic fibrosis was associated with multiple cardiovascular risk factors, including obesity, metabolic syndrome, diabetes, hypertension, and high-density lipoprotein cholesterol, even after accounting for covariates and CAP. Additional longitudinal studies are needed to determine if hepatic fibrosis contributes to incident cardiovascular disease risk factors or events.

SUBMITTER: Long MT

PROVIDER: S-EPMC8515503 | biostudies-literature | 2021 Feb

REPOSITORIES: biostudies-literature

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Publications

Hepatic Fibrosis Associates With Multiple Cardiometabolic Disease Risk Factors: The Framingham Heart Study.

Long Michelle T MT Zhang Xiaoyu X Xu Hanfei H Liu Ching-Ti CT Corey Kathleen E KE Chung Raymond T RT Loomba Rohit R Benjamin Emelia J EJ

Hepatology (Baltimore, Md.) 20210206 2

<h4>Background and aims</h4>NAFLD is increasing in prevalence and will soon be the most common chronic liver disease. Liver stiffness, as assessed by vibration-controlled transient elastography (VCTE), correlates with hepatic fibrosis, an important predictor of liver-related and all-cause mortality. Although liver fat is associated with cardiovascular risk factors, the association between hepatic fibrosis and cardiovascular risk factors is less clear.<h4>Approach and results</h4>We performed VCT ...[more]

PMID: 33125745

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Project description:Abstract Objectives Understanding the individual-level drivers of food choices is critical for designing personalized nutrition guidance. Taste perception is one factor, yet the effects of genetic variants (SNPs) related to taste perception on diet quality and cardiometabolic risk factors (CRFs) are unknown. Thus, our aims were to determine the associations of taste-related SNPs, combined as polygenic risk scores (PRS), with diet quality, and CRFs (waist circumference, glucose, systolic and diastolic blood pressure [SBP and DBP], and log[triglyceride] [TG] and HDL levels). Methods Cross-sectional analyses were conducted in 6,230 Framingham Heart Study Offspring (1998–2001) and Third Generation (2002–05) participants (mean age ± SD: 50 ± 14 y; 54% female). Diet quality was estimated using food group intakes (log[sev/wk]) derived from food frequency questionnaires. Weighted PRS were derived for tastes with ≥ 2 SNPs identified from prior GWAS (32 SNPs; 19 sweet, 9 bitter, 2 umami, 1 salt, 1 sour). Higher PRS indicated more alleles for higher taste perception. Associations were assessed via linear mixed models adjusted for age, sex, population stratification and energy intake. Results PRS were built for sweet, bitter, and umami perception (mean PRS ± SD: 19.5 ± 2.5, 5.3 ± 1.6, and 3.1 ± 0.8, respectively). Inverse associations were identified for PRSbitter and whole grains, PRSumami and vegetables, and PRSsweet and TG levels (β [95% CI] = −0.03 [−0.05, −0.02], −0.03 [−0.06, −0.01], and −0.008 [−0.014, −0.003], respectively) (all FDR <0.05). Exploratory analyses of individual SNPs identified associations (FDR <0.05) of sweet-related SNPs with higher fish/seafood and HDL levels, and lower TG levels; umami-related SNPs with lower vegetables; and a bitter-related SNP with lower SBP and DBP. Novel SNP-diet interactions were also identified; for example, higher fish/seafood intake was associated with lower TG levels for those with GG for salt-related SNP rs10134414 (G>A; G = higher perception), but higher TG levels for those with AA/AG (P=0.002). Conclusions Among community-dwelling adults, sweet-, bitter- and umami-related genes were associated with diet quality and CRFs, suggesting that taste-related genes impact food choices and may be beneficial to consider when personalizing risk reduction dietary guidance. Funding Sources AHA pre-doctoral fellowship #837,466 (JEG).

Dataset Information

Hepatic Fibrosis Associates With Multiple Cardiometabolic Disease Risk Factors: The Framingham Heart Study.

Background and aims

Approach and results

Conclusions

Publications

Hepatic Fibrosis Associates With Multiple Cardiometabolic Disease Risk Factors: The Framingham Heart Study.

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