The mechanism of cell death induced by silver nanoparticles is distinct from silver cations.

ABSTRACT:

Background

Precisely how silver nanoparticles (AgNPs) kill mammalian cells still is not fully understood. It is not clear if AgNP-induced damage differs from silver cation (Ag⁺), nor is it known how AgNP damage is transmitted from cell membranes, including endosomes, to other organelles. Cells can differ in relative sensitivity to AgNPs or Ag⁺, which adds another layer of complexity to identifying specific mechanisms of action. Therefore, we determined if there were specific effects of AgNPs that differed from Ag⁺ in cells with high or low sensitivity to either toxicant.

Methods

Cells were exposed to intact AgNPs, Ag⁺, or defined mixtures of AgNPs with Ag⁺, and viability was assessed. The level of dissolved Ag⁺

SUBMITTER: Rohde MM 

PROVIDER: S-EPMC8515661 | biostudies-literature | 2021 Oct

REPOSITORIES: biostudies-literature