Hydrogen sulfide prevents arterial medial calcification in rats with diabetic nephropathy.

ABSTRACT:

Background

Arterial medial calcification (AMC) is associated with a high incidence of cardiovascular risk in patients with type 2 diabetes and chronic kidney disease. Here, we tested whether hydrogen sulfide (H₂S) can prevent AMC in rats with diabetic nephropathy (DN).

Methods

DN was induced by a single injection of streptozotocin and high-fat diet (45% kcal as fat) containing 0.75% adenine in Sprague-Dawley rats for 8 weeks.

Results

Rats with DN displayed obvious calcification in aorta, and this was significantly alleviated by Sodium Hydrosulfide (NaHS, a H₂S donor, 50 μmol/kg/day for 8 weeks) treatment through decreasing calcium and phosphorus content, ALP activity and calcium deposition in aorta. Interestingly, the main endogenous H₂

SUBMITTER: Wang FZ 

PROVIDER: S-EPMC8515673 | biostudies-literature | 2021 Oct

REPOSITORIES: biostudies-literature