Lipidomics analysis of human follicular fluid form normal-weight patients with polycystic ovary syndrome: a pilot study.

ABSTRACT:

Background

The polycystic ovary syndrome (PCOS) is the most common endocrine associated with insulin resistance, even in the absence of overweight. The global lipid profile of the follicular fluid in PCOS with normal weight as yet has not been investigated. The objection of this pilot study was to explore the changes of lipids in the follicular fluid of PCOS with normal weight.

Methods

Follicular fluid samples were collected from patients who underwent IVF, including normal-weight women without PCOS (control group, n = 10) and normal-weight women with PCOS (PCOS group, n = 8). A lipidomic analysis was performed by high performance liquid chromatography/ mass spectrometry (HPLC-MS). Multidimensional statistical analysis was performed to disclose the global differences between

SUBMITTER: Ban Y 

PROVIDER: S-EPMC8515674 | biostudies-literature | 2021 Oct

REPOSITORIES: biostudies-literature