N6-Methyladenosine Modification of PTTG3P Contributes to Colorectal Cancer Proliferation via YAP1.

ABSTRACT:

Background

Long noncoding RNAs (lncRNAs) have emerged to have irreplaceable roles in the epigenetic regulation of cancer progression, but their biological functions in colorectal cancer (CRC) remain unclear.

Methods

LncRNA expression profiles in CRC tissue and their normal counterpart were explored. Through gain and loss of function approaches, the role of lncRNA PTTG3P was validated in relevant CRC cells and subcutaneous tumor model. The correlations of PTTG3P expression with clinical outcomes were assessed.

Results

PTTG3P was upregulated in CRC tissues and was closely correlated with unsatisfactory prognosis. PTTG3P facilitated glycolysis and proliferation, and the transcriptional regulator YAP1 was necessary for PTTG3P-induced proliferation. Mechanistically, the N6

SUBMITTER: Zheng Y 

PROVIDER: S-EPMC8515845 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature