Hamster and ferret experimental infection with intranasal low dose of a single strain of SARS-CoV-2.

ABSTRACT: Understanding the pathogenesis of the SARS-CoV-2 infection is key to developing preventive and therapeutic strategies against COVID-19, in the case of severe illness but also when the disease is mild. The use of appropriate experimental animal models remains central in the in vivo exploration of the physiopathology of infection and antiviral strategies. This study describes SARS-CoV-2 intranasal infection in ferrets and hamsters with low doses of low-passage SARS-CoV-2 clinical French isolate UCN19, describing infection levels, excretion, immune responses and pathological patterns in both animal species. Individual infection with 10³ p.f.u. SARS-CoV-2 induced a more severe disease in hamsters than in ferrets. Viral RNA was detected in the lungs of hamsters but not of ferr

SUBMITTER: Monchatre-Leroy E 

PROVIDER: S-EPMC8515860 | biostudies-literature | 2021 Mar

REPOSITORIES: biostudies-literature