Circuit reorganization in the Drosophila mushroom body calyx accompanies memory consolidation.

ABSTRACT: The formation and consolidation of memories are complex phenomena involving synaptic plasticity, microcircuit reorganization, and the formation of multiple representations within distinct circuits. To gain insight into the structural aspects of memory consolidation, we focus on the calyx of the Drosophila mushroom body. In this essential center, essential for olfactory learning, second- and third-order neurons connect through large synaptic microglomeruli, which we dissect at the electron microscopy level. Focusing on microglomeruli that respond to a specific odor, we reveal that appetitive long-term memory results in increased numbers of precisely those functional microglomeruli responding to the conditioned odor. Hindering memory consolidation by non-coincident presentation of odor and r

SUBMITTER: Baltruschat L 

PROVIDER: S-EPMC8515896 | biostudies-literature | 2021 Mar

REPOSITORIES: biostudies-literature