Ontology highlight
ABSTRACT:
SUBMITTER: Haque M
PROVIDER: S-EPMC8516052 | biostudies-literature | 2021 Oct
REPOSITORIES: biostudies-literature
Haque Muhammed M Forte Nafsika N Baker James R JR
Chemical communications (Cambridge, England) 20211014 82
Site-selective protein modification is of significant interest in chemical biology research, with lysine residues representing a particularly challenging target. Whilst lysines are popular for bioconjugation, due to their nucleophilicity, solvent accessibility and the stability of the resultant conjugates, their high abundance means site-selectivity is very difficult to achieve. Antibody-drug conjugates (ADCs) present a powerful therapeutic application of protein modification, and have often rel ...[more]