Predicting drug targets by homology modelling of Pseudomonas aeruginosa proteins of unknown function.

ABSTRACT: The efficacy of antibiotics to treat bacterial infections declines rapidly due to antibiotic resistance. This problem has stimulated the development of novel antibiotics, but most attempts have failed. Consequently, the idea of mining uncharacterized genes of pathogens to identify potential targets for entirely new classes of antibiotics was proposed. Without knowing the biochemical function of a protein, it is difficult to validate its potential for drug targeting; therefore, the functional characterization of bacterial proteins of unknown function must be accelerated. Here, we present a paradigm for comprehensively predicting the biochemical functions of a large set of proteins encoded by hypothetical genes in human pathogens to identify candidate drug targets. A high-throughput approach

SUBMITTER: Babic N 

PROVIDER: S-EPMC8516228 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature