Regulation of transcription reactivation dynamics exiting mitosis.

ABSTRACT: Proliferating cells experience a global reduction of transcription during mitosis, yet their cell identity is maintained and regulatory information is propagated from mother to daughter cells. Mitotic bookmarking by transcription factors has been proposed as a potential mechanism to ensure the reactivation of transcription at the proper set of genes exiting mitosis. Recently, mitotic transcription and waves of transcription reactivation have been observed in synchronized populations of human hepatoma cells. However, the study did not consider that mitotic-arrested cell populations progressively desynchronize leading to measurements of gene expression on a mixture of cells at different internal cell-cycle times. Moreover, it is not well understood yet what is the precise role of mitotic boo

SUBMITTER: Sarnataro S 

PROVIDER: S-EPMC8516288 | biostudies-literature | 2021 Oct

REPOSITORIES: biostudies-literature