Population-based identification and temporal trend of children with primary nephrotic syndrome: The Kaiser Permanente nephrotic syndrome study.

ABSTRACT:

Introduction

Limited population-based data exist about children with primary nephrotic syndrome (NS).

Methods

We identified a cohort of children with primary NS receiving care in Kaiser Permanente Northern California, an integrated healthcare delivery system caring for >750,000 children. We identified all children <18 years between 1996 and 2012 who had nephrotic range proteinuria (urine ACR>3500 mg/g, urine PCR>3.5 mg/mg, 24-hour urine protein>3500 mg or urine dipstick>300 mg/dL) in laboratory databases or a diagnosis of NS in electronic health records. Nephrologists reviewed health records for clinical presentation and laboratory and biopsy results to confirm primary NS.

Results

Among 365 cases of confirmed NS, 179 had confirmed primary NS attributed to presumed min

SUBMITTER: Parikh RV 

PROVIDER: S-EPMC8516311 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature