Decidual CXCR4⁺ CD56^bright NK cells as a novel NK subset in maternal-foetal immune tolerance to alleviate early pregnancy failure.

ABSTRACT: Natural killer (NK) cells preferentially accumulate at maternal-foetal interface and are believed to play vital immune-modulatory roles during early pregnancy and related immunological dysfunction may result in pregnant failure such as recurrent miscarriage (RM). However, the mechanisms underlying the establishment of maternal-foetal immunotolerance are complex but clarifying the roles of decidual NK (dNK) cells offers the potential to design immunotherapeutic strategies to assist RM patients. In this report, we analysed RNA sequencing on peripheral NK (pNK) and decidual NK cells during early pregnancy; we identified an immunomodulatory dNK subset CXCR4⁺ CD56^bright dNK and investigated its origin and phenotypic and functional characteristics. CXCR4⁺ CD56

SUBMITTER: Tao Y 

PROVIDER: S-EPMC8516340 | biostudies-literature | 2021 Oct

REPOSITORIES: biostudies-literature