Association between comorbidities and disease activity in axial spondyloarthritis: results from the BSRBR-AS.

ABSTRACT:

Objective

Whether comorbidities influence disease activity assessment in axial SpA (axSpA) is unclear. Comorbidities inflate DAS28 in rheumatoid arthritis through the patient global score. We examined whether axSpA disease activity measures are differentially affected, and whether comorbidities inflate the AS disease activity score (ASDAS) through the patient global component.

Methods

We used baseline data from the British Society for Rheumatology Biologics Register for AS, including 14 physician diagnosed comorbidities. Linear models were used to compare disease activity (BASDAI, spinal pain, ASDAS) and ESR/CRP according to comorbidity count, adjusted for age, gender, BMI, smoking, socioeconomic status, and education. The same models were used to examine whether the patient

SUBMITTER: Zhao SS 

PROVIDER: S-EPMC8516505 | biostudies-literature | 2021 Jul

REPOSITORIES: biostudies-literature