Declines in Pneumonia Mortality Following the Introduction of Pneumococcal Conjugate Vaccines in Latin American and Caribbean Countries.

ABSTRACT:

Background

Pneumococcal conjugate vaccines (PCVs) are recommended for use in pediatric immunization programs worldwide. Few data are available on their effect against mortality. We present a multicountry evaluation of the population-level impact of PCVs against death due to pneumonia in children < 5 years of age.

Methods

We obtained national-level mortality data between 2000 and 2016 from 10 Latin American and Caribbean countries, using the standardized protocol. Time series models were used to evaluate the decline in all-cause pneumonia deaths during the postvaccination period while controlling for unrelated temporal trends using control causes of death.

Results

The estimated declines in pneumonia mortality following the introduction of PCVs ranged from 11% to 35% am

SUBMITTER: de Oliveira LH 

PROVIDER: S-EPMC8516507 | biostudies-literature | 2021 Jul

REPOSITORIES: biostudies-literature